Abstract
Abstract A series of new coumarin linked with pyrimidine derivatives have been synthesized via microwave irradiation. Structures of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, GC-MS and CHN analysis techniques. All newly synthesized compounds screened for their in-vitro anti-microbial and anti-cancer activities (Hela and A549 Cell lines). Further DNA cleavage studied and reports revealed that most of the synthesized compounds inhibit the growth of the pathogenic organism by genome cleavage as no traces of DNA were found. The present investigation points out that the synthesized coumarin-pyrimidine analogs are promising in targeted drug delivery systems, can be used for cancer therapy. Docking results also supported the studies. A good pharmacokinetic profile is suggested by theoretical calculation of ADME properties. Insights into enzyme inhibitor interactions provided by docking stimulations and permitted us to rationalize the observed SARs.
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