Abstract
The microwave-induced three-component one-pot synthesis of 2-amino-3-carbethoxy-4-phenylpyrano[3,2-c]quinolin-5(6H)-ones (4a–l) from 4-hydroxyquinolin-2(1H)-ones, aromatic aldehydes and ethyl cyanoacetate was described. The detailed synthesis, structure analysis, and antimicrobial screening for the title compounds were also reported. Pharmacological screen studies like anti-inflammatory and antibacterial activities of newly synthesized quinoline derivatives were evaluated against carrageenan-induced rat paw edema model and Gram-positive and Gram-negative bacteria, respectively. A base catalyzed three-component one-pot synthesis of pyrano[3,2-c]quinolines are reported. A selective angular cyclization product was obtained with good yield rather than linear product. Pharmacological screening of newly synthesized quinoline derivatives were evaluated against carrageenan induced rat paw edema model and bactericides.
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