Microwave needle thermal effect enhenced by cisplatin-ferric powder reduced partical suspl in pig liver

Abstract

Objective To detect the thermal effect of microwave needle enhanced by cisplatin-ferric powder reduced partical suspl in pig liver.Methods One ml of cisplatin-ferric powder reduced partical (Fe content:95.53 g/L,and cisplatin:9.52 g/L) suspl was injected into pig liver,then the microwave needle (30,and 60 W) was used to heat the same site.Five and 10 min later the local temprature and the hot body diameters were measured by using infrared ray temprature detector.Ten min and 24 h later the local cisplatin contents were determined by using high performance liquid chromatography (HPLC).Results After the microwave heating lasted for 5-10 mint,the local temprature in the low (30 W) energy group,the high (60 W) energy group and the control group (cisplatin injection,60 W) was 45-75,55-95,and 45-75 ℃C,and the hot body diameters (over 45℃) were 2.79-3.36,3.10-3.50 and 2.32-2.85 cm,respectively.The local cisplatin contents in the low (30 W) energy group,the high (60 W) energy group and the control group (cisplatin injection,60 W) were (2.19 ±0.17),(2.10 ±0.13) and (2.35 ±0.16) g/L respectively,and 24 h later they were (1.81 ±0.12),(1.98 ±0.10) and (0.54 ±0.19) g/L respectively (P＜0.01).Conclusion The local temprature of cisplatin-ferric powder reduced partical suspl in pig liver can be easily increased to 45-95℃C by the microwave needle,and the hot body diameters were greater and the local cisplatin contents were higher than the usual. Key words: Fe ; Micromave ; Cisplatin ; Liver; Thermal effect