Microwave Irradiation Technique: A Green Chemistry Approach for Dissolution Enhancement of Ritonavir

Abstract

This research was focused on improvement of aqueous solubility of Ritonavir (RIT), Antiretroviral (ART) drug by preparing solid dispersion (SD) through solvent methodology and microwave irradiation (MWI) technique as a green chemistry approach. In MWI different batches of SD were formulated by 32 factorial approach with time of exposure (X1) and power of radiation (X2) as variable quantity and dissolution rate as response (Y1). β-CD was used as hydrophilic carriers. Drug carrier magnitude relation of 1:1 resolve by phase solubility analysis and SD were assessed for drug content, percentage dissolution rate studies, FTIR, XRD, DSC and SEM analysis. The FTIR, XRD, DSC and SEM studies exhibited no interaction between RIT and excipient. In Physical mixture (PM) it shows less intensity and disappearance of sharp peaks while in SD indicates the conversion of crystalline state of RIT to amorphous state that discovered the dissolution enhancing, so the SD prepared by MWI proved to be a promising approach to increasing the dissolving rate of BCS class II drug RIT. Hence, from the all analysis studies, it absolutely was evident that factorial batch F2 was the higher. F2 coded batch (RIT: β-CD within the magnitude relation of 1:1 with time of exposure (4 min) and power of radiation (450 Watt), shows 06 folds increase i.e. 58% compared with drug discharged inside 60 min to plane RIT and SD i.e. 9 % only and 47 % respectively.