Abstract
AbstractUnder microwave irradiation from natural amino acids to nitrogen heterocyclic compounds, a tandem reaction of hydroamination and oxidative cyclization has been explored. Utilizing amino acids and diethyl acetylenedicarboxylate with high product yields on 83–95%, functionalized pyrrole derivatives can be prepared during 0.5‐0.75 h by copper oxide catalysis. With nonpolar side chains natural amino acids can be used to develop microwave‐assisted one‐pot transformations. Reaction conditions also adapt to other dialkyl acetylenedicarboxylates such as dimethyi acetylenedicarboxylate. Besides the reaction regulation was illustrated.
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