Abstract
A microwave unit interfaced with a gas-loading accessory is used as a tool for facilitating the palladium-catalyzed decarboxylative Heck reaction of 2,6-dimethoxybenzoic acid and methyl acrylate, using molecular oxygen as the oxidant. The reaction is complete in less time and at a lower catalyst loading than when using conventional approaches. The reaction is scaled up using continuous-flow processing, employing a reactor in which both gas input and heating can be performed simultaneously. An 86% isolated product yield is obtained. This proof-of-principle study paves the way for the technology to be used in other cases of these increasingly popular decarboxylative coupling reactions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
