Abstract
The microwave-enhanced hydrogen–deuterium exchange reaction of a number of nitrogen-containing heterocyclic compounds has been achieved extremely rapidly (<20 min) via their hydrochloride salts, whilst the corresponding Raney-nickel catalysed reactions of indole and N-methylindole are also complete in a similar time interval. Furthermore, the pattern of labelling in the latter reaction depends critically on the choice of solvent used.
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