Abstract
Surfactants may elicit several undesirable effects on the skin. The stratum corneum is one of the targets showing primary changes after a short contact with detergents. Corneosurfametry was introduced as an ex vivo bioassay to assess the interaction and compatibility of surfactants with human stratum corneum. The present work introduces a variant of the regular corneosurfametry test. Microwaving set at 750 W for 30 s was used to shorten the duration of the technical procedure and to allow the rating of neat surfactant-containing products. The color of samples (L.* and Chroma C*) was measured to derive the colorimetric index of mildness (CIM), the values of which rise from 0 to 70 with increasing surfactant mildness toward human stratum corneum. Data were compared with standard corneosurfametry performed at 20 and 40°C. Data indicate that increasing the temperature of the test solutions and microwaving alter the CIM values of most surfactants. Only the most gentle products are little affected. An overall good correlation exists between the regular and microwave corneosurfametry data. Microwave corneosurfametry is a new sensitive tool for predicting skin compatibility of surfactants.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.