Microwave-assisted synthesis of thieno[2,3- c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A 1 receptor

Abstract

The microwave-assisted aromatization method has been used for the synthesis of a series of novel thieno[2,3- c]pyridines. This rapid method produces compounds in good yield within minutes in comparison with conventional heating method. The synthesized molecules have been evaluated as a potential new series of allosteric enhancers acting at the adenosine A 1 receptor. In a functional assay, one compound ( 3h) showed activity comparable with that of reference compound PD 81,723.