Microwave assisted synthesis of Thiacalix[n]arenes

Abstract

As a part of our ongoing investigations to unfold the chemistry of thiacalixarenes, this communication presents microwave assisted synthesis of thiacalix[n]arene macrocycles. This methodology entails combination of conventional heating and microwave irradiation to synthesize the entire series of thiacalix[n]arene analogs (n = 4, 5, 6, 7 and 8) with optimal yields and reaction time. LC-MS was used to monitor the progress/outcome of such reactions.