Abstract
Objective: To detect the microwave-assisted synthesis of Tetrahydropyrimidine derivative and its molecular docking studies for Diabetes.
 Methods: The Bignelli condensation method was used for Tetrahydropyrimidine derivative synthesis. The docking studies made in Argus Lab software.
 Results: The Tetrahydropyrimidine is synthesized using the microwave. The Tetrahydropyrimidine derivative is found to be attack the insulin receptor, as it the tendency of binding with insulin receptor showed in Argus lab. Further, the good binding site of Tetrahydropyrimidine derivative with insulin receptor was predicted.
 Conclusion: From the research work, The Tetrahydropyrimidine derivative shows its affinity to bind with the insulin receptor. The binding value is averagely 7 which indicates it can attraction with the receptor, so it can control Diabetic mellitus by altering insulin secretion in blood plasma.
Highlights
Diabetes mellitus is characterised by abnormally high levels of glucose in the blood due to an abnormal level of insulin secretion [1]
Diabetes is treated by oral medication and lifestyle modification, oral medication is based on providing blood glucose lowering drug [5]
The phosphorylated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analogue receptor is viewed in chimera, remove the complexed compound present in the receptor, further view it in Argus lab and add hydrogen to the receptor so as to increase affinity
Summary
Diabetes mellitus is characterised by abnormally high levels of glucose in the blood due to an abnormal level of insulin secretion [1]. The diabetes shows the combined effect of hyperglycaemic with long period damage or malfunction or death of some organ [2]. Several pathogenic process are involved in the development of diabetes. Diabetes affected more 425 million people in the world, In India more than 742,946,400 case were studied in adult [3]. Diabetes is mainly classified as two types; 1) Type- Diabetes which is complete destruction of insulin, 2) Type- Diabetes which is inadequate supply of insulin [4]. Diabetes is treated by oral medication and lifestyle modification, oral medication is based on providing blood glucose lowering drug [5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Current Pharmaceutical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
