Microwave Assisted Synthesis of Pyrimidine Carboxamide Catalyzed by Ruthenium Chloride and their Antioxidant Studies

Abstract

A systematic and simple method for the preparation of pyrimidinone compound utilizing RuCl3.2H2O catalyst under traditional and microwave method. The preparation of dihydro pyrimidinone utilizing ruthenium chloride dihydrate had generated lots of interest which includes easy work up, less reaction period and better yields under the usage of CH3CN as a solvent. The structures of the new substances have been affirmed throgh FT-IR, 13C NMR, 1H NMR and mass spectra. All the new substances were screened for antioxidant nature.