Microwave‐Assisted Synthesis of Porous Biomolecule‐Incorporated Metal‐Organic Frameworks as Efficient Nanocarriers for Anti‐Cancer Drugs

Abstract

AbstractBiomolecule‐incorporated metal‐organic frameworks (b‐MOFs) exhibit enhanced bioavailability and biocompatibility, making them an ideal option for use as drug delivery vehicles. While b‐MOFs possess outstanding drug loading and release capabilities, their microscale crystal sizes restrict their applicability as nanocarriers and drug delivery systems. To overcome this limitation, this paper presents a microwave‐irradiation‐based technique for the synthesis of porous adenine‐incorporated Zn‐based MOFs with particle sizes of approximately 200 nm as paclitaxel nanocarriers. The nanomaterial demonstrated a substantial paclitaxel loading capacity of 637 mg g−1. Moreover, it effectively increased the solubility of paclitaxel by 2.5‐fold compared to that of the free form. Thus, the nano MOF is a promising delivery vehicle for paclitaxel. Notably, the paclitaxel‐loaded nano MOF exhibited higher toxicity toward cancer cells than the free drug, further highlighting its potential as an effective anticancer agent.