Abstract
Microwave-assisted synthesis of novel amide based chiral tripodal receptors for recognition of cation and anion sensors
Highlights
Selective recognition of cations and anions by artificial receptors has been an attractive research area for their potentials in various applications such as biochemical and pharmaceutical studies, separation processes and sensing.[1,2,3,4,5,6] Multiple interactions between hosts and guests are necessary in developing an artificial receptor exhibiting selectivity towards a specific analyst
Selectivity of a tripodal receptor largely depends on cavity size and rigidity of the arms[15,16,17] and they are known to have several advantages compared to monopodal and bipodal receptors: i) they usually bind metal ions very strongly due to increasing chelating influence, ii) bulkiness of tripodal ligands allows them to be more reactive towards metal ions
This paper involves the synthesis of a series of novel tripodal receptors based on amides under microwave conditions and the evaluation of their molecular recognition abilities towards various anions (H2PO4, HSO4, C6H5CO2, CH3CO2, F, Cl, Br-) and chiral organic ammonium cations using 1H NMR titration methods
Summary
Selective recognition of cations and anions by artificial receptors has been an attractive research area for their potentials in various applications such as biochemical and pharmaceutical studies, separation processes and sensing.[1,2,3,4,5,6] Multiple interactions between hosts and guests are necessary in developing an artificial receptor exhibiting selectivity towards a specific analyst. Tripodal based receptors have been used successfully in the ion-selective electrode membranes7,8a,b,9,10 and optical sensors.[11,12,13,14] They allow three arms as interacting sites for ligands. Because of the distinctive features of synthetic tripodal receptor system, their design and development is a very active field of study in the supramolecular chemistry.[6,7,18,19] An amide functional group, which exists in the structure of many synthetic materials, is very important in the organic chemistry and biochemistry. This paper involves the synthesis of a series of novel tripodal receptors based on amides under microwave conditions and the evaluation of their molecular recognition abilities towards various anions (H2PO4-, HSO4-, C6H5CO2-, CH3CO2-, F-, Cl-, Br-) and chiral organic ammonium cations using 1H NMR titration methods
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