Abstract
Chalcones are synthesized by Claisen-Schmidt condensation, which involves cross-aldol condensation of appropriate aldehydes and ketones by base catalyzed reaction, the new chalcone derivatives synthesized by the reaction aldehyde with their compounds. By microwave assisted synthesis, a considerable increase in the reaction rate has been observed and that too, with better yields. M.P., TLC, CHN, FTIR, NMR and MS spectroscopy has characterized all the synthesized compounds. The biological screening data of the synthesized compounds were also studied. Keywords : microwave, chalcone, antibacterial. DOI : 10.7176/CMR/11-3-05 Publication date :March 31 st 2019
Highlights
Microwave dielectric heating uses the ability of some liquids and solids to transform electromagnetic radiation into heat to drive chemical reactions
Chalcones are synthesized by Claisen-Schmidt condensation, which involves cross-aldol condensation of appropriate aldehydes and ketones by base catalyzed or acid catalyzed reaction followed by dehydration
In the present investigation, it has been considered worthwhile to synthesize some new chalcone derivatives by conventional and microwave irradiation methods and a comparison has been made between two methods
Summary
Microwave dielectric heating uses the ability of some liquids and solids to transform electromagnetic radiation into heat to drive chemical reactions. In the present investigation, it has been considered worthwhile to synthesize some new chalcone derivatives by conventional and microwave irradiation methods and a comparison has been made between two methods. The reaction was monitored by TLC using eluent www.iiste.org n-hexane: ethyl acetate (3:7), the obtained product white crystals was filter off and recrystallized from ethanol to give 1-(4-Acetylphenyl)-3-phenylthiourea (m.p. 160-162oC).
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