Abstract
A series of polycarbonate copolymers were synthesized by microwave-assisted ring-opening polymerization of ɛ-caprolactone (CL) and 2-phenyl-5,5-bis(oxymethyl) trimethylene carbonate (PTC) with Tin (II) 2-ethylhexanoate as a catalyst. These copolymers obtained were detected by 1H NMR, FT-IR, UV, gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and automatic contact angle meter. The influences of the feed molar ratio of monomers, catalyst concentration, reaction time and reaction temperature, as well as microwave irradiation power on the copolymerization process were also studied. In vitro degradation tests indicated that these polycarbonate copolymers possess the slow degradation rates and strong hydrophobicity. In vitro release profiles of 5-Fu from copolymers showed that copolymers have the steady drug release rates and good controlled release properties.
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