Abstract
A major concern in base catalyzed Henry reaction for the synthesis of β-nitroalcohol from the reaction of aldehyde and nitroalkane is instantaneous formation of nitroalkene by dehydration, which in turn facilitates many side reactions. It is observed that rapid synthesis of β-nitroalcohol can be accomplished by carrying out the reaction in aqueous phosphate buffer at pH 7.0 under microwave irradiation without using any additional base. Use of microwave irradiation facilitated the formation of β-nitroalcohol within a very short time, yet no instantaneous formation of nitroalkene was observed even at 80 °C.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
