Abstract
Microwave-assisted rapid extracellular biosynthesis of silver nanoparticles was carried out by using carom seed (Trachyspermum copticum) extract as the reducing agent. The reaction mixture containing AgNO3 and carom seed extract when exposed to microwave irradiation resulted in reducing silver ions to bio-functionalized silver nanoparticles of size 6- 50 nm. The AgNP were characterized by UV-vis spectroscopy (UV-vis), X-ray diffraction (XRD), energy dispersive X-ray analysis (EDAX), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and atomic force microscopy (AFM). Themogravimetric analysis (TGA) and fourier transform infrared spectroscopy (FTIR) are used to understand the possible mechanism of biosynthesis. In this study, we have also investigated the antimicrobial and antioxidant activities of bio-functionalized AgNP. The antibacterial activity is investigated by measuring the zone of inhibition and antioxidant study is done using 1,1-diphenyl-2-picryl hydrazyl (DPPH) method.
Highlights
The perfection to unfold and view the structure and function of life at the nano level is leading to rapid development in technology [1] and health sciences [2]
It can be expected that the high fraction of surface atoms of silver nanoparticles (AgNP) will lead to an excellent antimicrobial activity when compared to bulk Ag metal [5]
We report on the microwave-assisted rapid synthesis of highly stable bio-functionalized AgNP using carom seed extract as a reducing agent
Summary
The perfection to unfold and view the structure and function of life at the nano level is leading to rapid development in technology [1] and health sciences [2]. It can be expected that the high fraction of surface atoms of silver nanoparticles (AgNP) will lead to an excellent antimicrobial activity when compared to bulk Ag metal [5]. AgNP are currently used as active drug in targeted drug delivery [6], gene delivery [7] and artificial implants [8] and as a diagnostic agent in imaging and sensors for detection of different diseases in their early stages. We report on the microwave-assisted rapid synthesis of highly stable bio-functionalized AgNP using carom seed extract as a reducing agent. Though the antibacterial activity of AgNP is being studied extensively, reports on the effect of these bio-functionalized nanoparticles in particular are rare. Our results support simple and cost-effective production of stable functionalized AgNP which are suitable for formulation of new types of bactericidal medicines
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