MICROWAVE ASSISTED PICTET-SPENGLER SYNTHESIS OF SOME TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR BIOLOGIAL EFFICACY STUDIES.

Sachins Chourasia,Pralhadk Rahangdale,Farhin Inam

doi:10.21474/ijar01/4310

Abstract

29May 2017 MICROWAVE ASSISTED PICTET-SPENGLER SYNTHESIS OF SOME TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR BIOLOGIAL EFFICACY STUDIES. Sachin S. Chourasia , Pralhad K. Rahangdale and Farhin Inam. Assistant Professor and Head, Department of Chemistry, M. B. Patel College, Deori, 441901(M.S.), India. Associate Professor and Head, Department of Chemistry, Bhawabhuti. College, Amgaon, 441902(M.S.), India. Associate Professor, Govt. Vidarbha Institute of Science and Humanities, Amravati, 444604(M.S.), India.

Highlights

The synthesized THIQ derivatives were screened for isoquinoline derivatives, pictet-spengler synthesis, antibacterial activity
Isoquinoline in the form of 1,2,3,4tetrahydroquinoline scaffold occurs in a large number of alkaloids [2,3,4,5,6,7,8,9].The Bischler-Napieralski [10] suggested the new method for the synthesis of isoquinoline
Bergstrom [11] reported Pictet-Spengler Reaction (PSR) for synthesis of substituted isoquinolines. These two methods have been found to be reliable methods for synthesis of tetrahydroisoquinoline wherein N-acyl-β-arylethylamine or β-arylethylamine derivative is treated with an aldehyde under acidic condition to generate imine

Summary

Introduction

The synthesized THIQ derivatives were screened for isoquinoline derivatives, pictet-spengler synthesis, antibacterial activity. Bergstrom [11] reported Pictet-Spengler Reaction (PSR) for synthesis of substituted isoquinolines.

Results

Conclusion