Abstract
Some new trifluoromethyl coumarin thiosemicarbazones 3a-3m were synthesized by condensation reaction of thiosemicarbazides and 3-trifluoroacetyl coumarins which was from recyclization of ethyl 2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylates under microwave assisted and solvent-free conditions. The structure of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, HRMS and X-ray, and their antifungal activity was evaluated. Most of them exhibited potent antifungal activity by comparison with the standard drugs. Keywords: Antifungal activity, microwave synthesis, one-pot synthesis, solvent-free, trifluoromethyl coumarin thiosemicarbazones.
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