Microwave-assisted one-pot synthesis of 2,3-disubstituted 3 H-quinazolin-4-ones

Abstract

A practical synthesis of 2,3-disubstituted 3 H-quinazolin-4-ones 1 with broad chemistry scope is described. The key step is the microwave promoted one-pot, two-step reaction sequence combining anthranilic acids, carboxylic acids, and amines providing efficient access to this important class of heterocycles.