Abstract
Synthetic calcium phosphate (CaP)-based materials have attracted much attention in the biomedical field. In this study, we have investigated the effect of pH values on CaP nanostructures prepared using a microwave-assisted hydrothermal method. The hierarchical nanosheet-assembled hydroxyapatite (HAP) nanostructure was prepared under weak acidic conditions (pH 5), while the HAP nanorod was prepared under neutral (pH 7) and weak alkali (pH 9) condition. However, when the pH value increases to 11, a mixed product of HAP nanorod and tri-calcium phosphate nanoparticle was obtained. The results indicated that the pH value of the initial reaction solution played an important role in the phase and structure of the CaP. Furthermore, the protein adsorption and release performance of the as-prepared CaP nanostructures were investigated by using hemoglobin (Hb) as a model protein. The sample that was prepared at pH = 11 and consisted of mixed morphologies of nanorods and nanoprisms showed a higher Hb protein adsorption capacity than the sample prepared at pH 5, which could be explained by its smaller size and dispersed structure. The results revealed the relatively high protein adsorption capacity of the as-prepared CaP nanostructures, which show promise for applications in various biomedical fields such as drug delivery and protein adsorption.
Highlights
Calcium phosphate (CaP) materials have attracted much attention in the biomedical field, due to their excellent biocompatibility [1,2,3]
These results indicate that the pH value has an important influence on the morphology and structure of calcium phosphate (CaP) materials prepared with the microwave-assisted hydrothermal method
These results indicate that the pH value of the reaction solution has an obvious effect on the crystal phase of CaP nanostructures prepared by microwave-assisted hydrothermal method
Summary
Calcium phosphate (CaP) materials have attracted much attention in the biomedical field, due to their excellent biocompatibility [1,2,3]. The synthetic CaP nanomaterials are deemed to be good for biocompatibility and bioactivity, and have been widely investigated in various applications, including drug delivery [9], protein adsorption [10], bone defect repair/tissue engineering [11,12], and other biomedical areas [13,14]. Microwave heating technology has become a fast-growing area of research in synthetic chemistry, and has been widely used in the synthesis of various inorganic nanostructured materials including CaP biomaterials [22,23]. Various CaP nanostructured materials have been prepared by the microwave-assisted method in liquid phase, including nanoparticles and one-, two- and three-dimensional nanostructures [1,24,25,26]. The as-prepared CaP nanostructures are promising for applications in various biomedical fields such as drug delivery and protein adsorption
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