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Abstract
As a target to synthesize various Thiazolidinone derivatives, 2‐Amino‐4‐(coumarin‐3‐yl)‐thiazole has been prepared by the reactions of 3‐Bromo acetyl coumarin with thiourea. 3‐Bromo acetyl coumarin was prepared from 3‐Acetyl coumarin. The resulting compound 2‐amino‐4‐(coumarin‐3‐yl)‐ thiazole was treated with different Aldehydes to give the intermediate Schiff base, which on further reaction with Thioglycolic acid and Thiolactic acid to give titled compound Thiazolidinone. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. The antibacterial activity of the compounds has also been screened against Staphylococcus aureus and Escherichia coil.
Highlights
A survey of literature reveals that Thiazolo Coumarins posses a broad spectrum of biological importance
Schiff Base gives good antimicrobial activity and pharmacological applications[3] and it can be prepared by the acid catalyzed reaction of amines & Ketones or Aldehydes
Under the framework of “Green Chemistry” we have developed an environmentally benign synthesis of Thiazolidinones
Summary
A survey of literature reveals that Thiazolo Coumarins posses a broad spectrum of biological importance. Key words Schiff Base, Thiazolidinone, Antibacterial activity. Thiazolo Coumarin derivatives are well known biologically active compounds. Schiff bases from 2-Amino-4- (coumarin-3-yl)-thiazole and various Aldehydes are reported to have significant antibacterial activity.
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