Abstract
The green synthesis of metal nanoparticles has been promising approach in the field of nanomedicine due to its low-cost, non-toxic, biocompatible and sustainable features. In literature, therapeutic potentials of silver nanoparticles (AgNPs) coupled with natural extracts have been extensively evaluated against various diseases. The present study aims at preparation of AgNPs using Coriolus versicolor and Boletus edulis mushroom extract based on the microwave-assisted method. The synthesized C. versicolor-silver nanoparticles (CV-AgNPs) and B. edulis-silver nanoparticles (BE-AgNPs) were characterized by UV–Visible spectroscopy, dynamic light scattering technique (DLS) and fourier transform infrared spectroscopy (FTIR). Anticancer activity of AgNPs was tested on MCF-7, HT-29 and HUH-7 cell lines. Antimicrobial efficacy of AgNPs was determined against pathogens bacterial (Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus and Enterococcus faecalis) and fungal (Candida albicans and Candida utilis) strains. Also, wound healing potential of AgNPs was examined on L929 cells. Obtained results demonstrated that synthesized CV-AgNPs and BE-AgNPs had an average size diameter of <100 nm and have strong anticancer, antibacterial, antifungal and wound healing potentials.
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