Abstract
A simple, efficient and expeditious method for synthesis of 2-arylbenzo[b]furans and 2-ferrocenylbenzo[b]furans from readily prepared propargylic alcohols, o-iodophenols and silica gel with the catalyst of PdCl2(PPh3)2 (2 mol%)/CuI (2 mol%) and microwave-promoted Sonogashira coupling/cyclization reaction is developed. The methodology can produce good to excellent yields. In addition, this method can also be completed in one-pot with iodobenzene, 2-methyl-3-butyn-2-ol and 2-iodo-4-methylphenol as reactants. A simple and efficient method for synthesis of 2-arylbenzo[b]furnas and 2-ferrocenylbenzo[b]furans has been developed from the Sonogashira coupling/cyclization reaction of propargylic alcohols and o-iodophenols in the presence of silica gel and catalytic amounts of PdCl2(PPh3)2 (2 mol%) and CuI (2 mol%) under microwave conditions.
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