Abstract
AbstractFunctionalized polysubstituted oxazoles are an important class of five‐membered N,O‐heterocycles that occur widely in the structure of natural products and fine chemicals. They are also often used as building blocks in the synthesis ofheterocyclic molecules with more complex structures. Therefore, efficient synthetic protocols based on Lewis acid promoted reactions are desirable. In this context, we report that, under microwave irradiation, the CeCl3·7H2O/NaI/I2 system is capable of promoting a 5‐exo‐dig cyclization of propargyl amides with good functional group tolerance. The microwave reactor also provides a more convenient and safer method for heating the reaction. This methodology represents a straightforward CeCl3·7H2O/NaI/I2 promoted cyclization using microwave irradiation to accomplish the synthesis of polysubstituted oxazole derivatives.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
