Abstract
The catalytic activity of a benzimidazole-oxime Pd(II)-complex towards Suzuki and Heck C-C cross-coupling reactions of activated and deactivated aryl- and heteroaryl bromides under microwave irradiation as well as thermal heating using water as a green solvent was evaluated. The turnover frequency reached 420,000 under microwave condition.
Highlights
Transition metal-mediated cross-coupling reactions, those based on palladium, have become key transformations in organic synthesis.[1]
The first microwave-assisted Suzuki cross-coupling reaction was reported in 1996.3 Our recent research work is directed to the use of palladium(II) complexes in Suzuki-Miyaura and Heck-Mizoroki cross-coupling reactions under microwave heating conditions in aqueous media.[4]
We examined the catalytic activity of the Pd(II)-complex 1 in cross-coupling reactions of 4-halophenylthiazoles,[5] we report general applications of the Pd(II)-complex 1 as a precatalyst in Suzuki and Heck cross-coupling reactions of aryl- and heteroaryl halides assisted with microwave irradiation using water as a green solvent
Summary
Transition metal-mediated cross-coupling reactions, those based on palladium, have become key transformations in organic synthesis.[1] there has been considerable interest in the development of new, highly-active palladium catalysts that can be used in C-C cross-coupling reactions. Microwave-assisted organic synthesis is advantageous for enabling rapid, reproducible, and scalable chemistry development in research laboratories and industrial processes.[2] The first microwave-assisted Suzuki cross-coupling reaction was reported in 1996.3 Our recent research work is directed to the use of palladium(II) complexes in Suzuki-. Miyaura and Heck-Mizoroki cross-coupling reactions under microwave heating conditions in aqueous media.[4] Very recently, we examined the catalytic activity of the Pd(II)-complex 1 in cross-coupling reactions of 4-halophenylthiazoles,[5] we report general applications of the Pd(II)-complex 1 as a precatalyst in Suzuki and Heck cross-coupling reactions of aryl- and heteroaryl halides assisted with microwave irradiation using water as a green solvent
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