Abstract
Background: Aminolysis of lactones is an important reaction for the synthesis of hydroxy amides. This reaction generally requires rather harsh conditions, such as high pressure and temperature or strong alkali metal catalysts. Microwave-assisted reactions have provided a great impetus to organic synthesis, especially for accelerating the reactions. The combination of microwave heating and solventfree conditions is a particularly attractive methodology in modern organic synthesis because it leads to enhanced conversion rates, easier work-up, higher yields and in general cleaner reactions. Keywords: Aminolysis, lactones, microwave irradiation, hydroxy amides.
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