Microvessel density is as a prognostic factor in canine cutaneous mast cell tumors

José Guilherme Xavier,José Luiz Catão-Dias,Lidia H Pulz,Nilton P Santos,Silvia Regina Kleeb,Ricardo F Strefezzi,Daniella FL Barbosa

doi:10.1186/1753-6561-7-s2-p62

José Guilherme Xavier, José Luiz Catão-Dias + Show 5 more

Open Access

https://doi.org/10.1186/1753-6561-7-s2-p62

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Abstract

Background Mast cell tumors represent almost 25% of canine skin neoplasms. These tumors are classified in three grades of differentiation, based on histological features. However, this grading system is a method based on subjective parameters, which generate intra- and interobserver variations. The microcirculation is an important feature to the primary tumor expansion, dissemination and metastasis, and there are essential evidences that increasing microvessel density is associated with short survival disease-free intervals. The purpose of the present study was to verify the prognostic value of the intratumoral microvessel density (IMVD) in a set of canine cutaneous mast cell tumors. Materials and methods Twenty-nine canine cutaneous mast cell tumors were subjected to immunohistochemical analysis using a rabbit polyclonal antibody anti-human von Willebrand Factor. Subsequently, the IMVD was determined by the average number of vessels in 5 low-power fields.

Highlights

The microcirculation is an important feature to the primary tumor expansion, dissemination and metastasis, and there are essential evidences that increasing microvessel density is associated with short survival disease-free intervals
Mast cell tumors represent almost 25% of canine skin neoplasms
The purpose of the present study was to verify the prognostic value of the intratumoral microvessel density (IMVD) in a set of canine cutaneous mast cell tumors

Summary

Introduction

Mast cell tumors represent almost 25% of canine skin neoplasms. These tumors are classified in three grades of differentiation, based on histological features. This grading system is a method based on subjective parameters, which generate intra- and interobserver variations. The microcirculation is an important feature to the primary tumor expansion, dissemination and metastasis, and there are essential evidences that increasing microvessel density is associated with short survival disease-free intervals. The purpose of the present study was to verify the prognostic value of the intratumoral microvessel density (IMVD) in a set of canine cutaneous mast cell tumors

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