Abstract
The efficiency of transdermal drug delivery may be increased by pretreating the skin with microneedles, but distinct effects of microneedles and the microneedle-enhanced delivery of vasoactive drugs on the skin microvasculature are still not well investigated. In eight healthy human subjects, we measured the microvascular response to microneedle-induced microtraumas in the skin microvasculature using polarized light spectroscopy imaging (Tissue Viability imaging, TiVi). The microvascular response was assessed for up to 48hours for three microneedle sizes (300µm, 500µm, and 750µm) and for different pressures and application times. In our results, microneedle application increased the local red blood cell (RBC) concentration for up to 24hours dependent on the needle lengths, applied time, and force. Optimization of microneedles size, pressure, and application time should be taken into account for future protocols for drug delivery and experimental provocations.
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