Abstract
PURPOSE: Microvascular blood flow alterations including heterogeneity of both the spatial distribution of perfused capillary densities, transit times, and local perfusion pressures are pivotal in the pathogenesis of sepsis. Such alterations are independent of the arterial pressure in animal studies. We designed a study using Orthogonal Polarization Spectral (OPS) imaging to further investigate the extent of the microvascular changes and correlate these to the severity of sepsis.
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