Abstract
Vessel Plus is an open acccess journal, which publishes articles related to vascular diseases, including acute respiratory distress syndrome, aneurysm, atherosclerosis, hypertension, stroke, peripheral vascular or pulmonary vascular diseases, etc.
Highlights
During cardiovascular surgery, cardioplegia (CP) and cardiopulmonary bypass (CPB) may influence in vivo vasomotor control and microvascular function, and as a result, affect organ perfusion
The focus will be on post-Cardioplegia and cardiopulmonary bypass (CP/CPB) alterations in myogenic tone, agonist-induced vasomotor tone, and endothelial dysfunction in the coronary and peripheral microvasculature
Myogenic tone is an intrinsic property of vascular smooth muscle in many vascular beds and plays an important role in regulation of the coronary and peripheral microcirculation
Summary
Cardioplegia (CP) and cardiopulmonary bypass (CPB) may influence in vivo vasomotor control and microvascular function, and as a result, affect organ perfusion. In a canine model reported in the same study, similar findings were apparent During this same period, left ventricular perfusion increased, mean arterial pressure and coronary vascular resistance decreased, and myocardial oxygen consumption was unchanged. Left ventricular perfusion increased, mean arterial pressure and coronary vascular resistance decreased, and myocardial oxygen consumption was unchanged These clinical and experimental studies suggest that major coronary vasodilatation occurring in the early period following CP/CPB when these modalities are used. In vitro microvascular studies may allow us to better examine changes in specific vasomotor pathways and mechanisms compared to the in vivo assessment of organ perfusion. The focus will be on post-CP/CPB alterations in myogenic tone, agonist-induced vasomotor tone, and endothelial dysfunction in the coronary and peripheral microvasculature
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