Abstract
BackgroundTo measure the microcirculation change of macula and optic nerve head before and after femtosecond laser assisted laser in situ keratomileusis.MethodsIn total 45 eyes from 45 subjects, who underwent FS-LASIK during June 2017 to December 2017 in Guangdong Provincial People’s Hospital, were recruited in this study. Vessel density in macula and optic nerve head were measured by optical coherence tomography angiography before and after transient elevation in intraocular pressure caused by application of suction ring during surgery.ResultsVessel density (VD) at superficial (SCP) plexus of macular region did not differ after surgery (F(3,132) = 1.41, P = 0.24), while the deep (DCP) plexus of macular region significantly decreased 1 day after surgery (P = 0.001) but returned to its baseline value 1 month postoperatively (P = 0.1). Vessel density of optic nerve head region had no significant changes after surgery (F(2.51,95.18) = 0.6, P = 0.59).ConclusionsA short-term temporary decrease of vessel density at deep layer of macular region was observed in eyes undergoing FS-LASIK. However, the retinal capillary density went back to preoperative level 1 month after surgery. Therefore, transient IOP spike during FS-LASIK did not cause long-term decline of retinal microcirculation.
Highlights
To measure the microcirculation change of macula and optic nerve head before and after femtosecond laser assisted laser in situ keratomileusis
The study followed the tenets of the Declaration of Helsinki and all subjects were thoroughly informed of the procedure and provided written informed consent
The Vessel density (VD) of whole macular image in superficial capillary plexuses (SCP) decreased after surgery, but the changes were not significant (F(3,132) = 1.41, P = 0.24)
Summary
To measure the microcirculation change of macula and optic nerve head before and after femtosecond laser assisted laser in situ keratomileusis. Femtosecond laser assisted laser in situ keratomileusis (LASIK) is currently one of the most commonly performed refractive surgery worldwide. A suction ring is applied on the anterior segments of the eye in order to immobilize the eyeball. Investigation revealed that sudden increase of IOP caused a temporary central retinal artery. Previous study has investigated a temporary increase in blood flow at the lamina cribrosa region of the optical nerve head after surgery [9]. While the change of macular blood flow was currently unknown. Optical coherence tomography angiography (OCTA) is a new noninvasive technique that can visualize the retinal vascular network and quantify the vascular density in the macular area and optical nerve head (ONH). Microcirculation in the macula and ONH were
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