Abstract
Characterized by ventricular stiffening and associated with diabetes, obesity and hypertension, heart failure with preserved ejection fraction (HFpEF) is emerging as the prevalent form of heart failure. Stabilized microtubules stiffen failing myocardium and therefore present a potential therapeutic target for HFpEF, but microtubule network remodeling remains largely uncharacterized in HFpEF. Thus we aimed to quantify microtubule stabilization and its impact on myocyte contractility and mechanics in an established model of HFpEF, the ZSF1 rat.
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