Abstract
EMBO J 31: 3063–3078 Successful axon regeneration relies on a sophisticated balance between stable and dynamic microtubules. While it has been established that moderate microtubule stabilization improves regenerative performance, little is known how microtubules are normally regulated during regeneration. A new study by Cho and Cavalli (2012) uncovers an early role for local microtubule deacetylation that seems important for converting a cut axon stump to a regenerating axon. The authors demonstrate that histone deacetylase 5 is responsible for local deacetylation, and that it is locally activated by PKC downstream of axotomy-induced calcium influx.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
