Abstract
Breast cancer is the leading cause of death by malignancy among women worldwide. Clinical data and molecular characteristics of breast tumors are essential to guide clinician’s therapeutic decisions. In the new era of precision medicine, that aims at personalizing the treatment for each patient, there is urgent need to identify robust companion biomarkers for new targeted therapies. This review focuses on ATIP3, a potent anti-cancer protein encoded by candidate tumor suppressor gene MTUS1, whose expression levels are markedly down-regulated in breast cancer. ATIP3 is a microtubule-associated protein identified both as a prognostic biomarker of patient survival and a predictive biomarker of breast tumors response to taxane-based chemotherapy. We present here recent studies pointing out ATIP3 as an emerging anti-cancer protein and a potential companion biomarker to be combined with future personalized therapy against ATIP3-deficient breast cancer.
Highlights
Breast cancer is the leading cause of death by malignancy among women worldwide
The present review focuses on the characterization of ATIP3 in breast cancer
We summarize recent results investigating intracellular mechanisms regulated by this protein and we present evidence that ATIP3 is a prognostic and predictive biomarker in breast tumors
Summary
Not determined; OS: Overall survival, DFS: disease-free survival, MFS: metastasis free survival; IHC: immunohistochemistry, RT-qPCR: Reverse transcription quantitative polymerase chain reaction; RNAseq: RNA sequencing; WB: Western blot. * Underexpression of MTUS1 is associated with reduced OS, MFS, and DFS
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