Abstract
Background HIV-specific cellular immune responses have been detected in some uninfected infants born to HIV-infected women, indicating transient virus exposure or replication has occurred. Small quantities of maternal blood pass into the infant's circulation during childbirth, termed “microtransfusion”, potentially facilitating viral exposure. We sought to determine the occurrence of microtransfusion and HIV-specific immune responses as an indicator of viral exposure in a cohort of uninfected infants born to HIV-infected women, in the context of interventions.
Highlights
HIV-specific cellular immune responses have been detected in some uninfected infants born to HIV-infected women, indicating transient virus exposure or replication has occurred
We sought to determine the occurrence of microtransfusion and HIV-specific immune responses as an indicator of viral exposure in a cohort of uninfected infants born to HIV-infected women, in the context of interventions
Infants were grouped according to interventions utilised by the mother: none or antiretroviral therapy (ART; group A, n = 16), ART with elective caesarean section, highly active antiretroviral therapy (HAART) only, and HAART with elCS
Summary
HIV-specific cellular immune responses have been detected in some uninfected infants born to HIV-infected women, indicating transient virus exposure or replication has occurred. Small quantities of maternal blood pass into the infant's circulation during childbirth, termed “microtransfusion”, potentially facilitating viral exposure. We sought to determine the occurrence of microtransfusion and HIV-specific immune responses as an indicator of viral exposure in a cohort of uninfected infants born to HIV-infected women, in the context of interventions
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