Abstract
This article presented 3 cases diagnosed with chronic fatigue syndrome, severe skin adjuvant infiltration and skin ulcers.
Highlights
Human adjuvant disease (HAD), first described by Miyoshi in 1973, is associated with exposure to foreign substances that can act as adjuvants, some of which are injected into patients for cosmetic purposes, including silicone, mineral oil, guaiacol, and others [1]
Human adjuvant disease is associated with the exposure to foreign substances that act as foreign bodies, some of which are injected into patients for cosmetic purposes, including silicone, mineral oil, guaiacol, and others
A new term -autoimmune/inflammatory syndrome induced by adjuvants has recently been coined with a process that includes several clinical features previously described by Miyoshi plus other clinical and laboratory parameters related to exposure to diverse external stimuli
Summary
Human adjuvant disease (HAD), first described by Miyoshi in 1973, is associated with exposure to foreign substances that can act as adjuvants, some of which are injected into patients for cosmetic purposes, including silicone, mineral oil, guaiacol, and others [1]. Human adjuvant disease is associated with the exposure to foreign substances that act as foreign bodies (adjuvants), some of which are injected into patients for cosmetic purposes, including silicone, mineral oil, guaiacol, and others. We presented 3 cases of lower extremities HAD treated by the extensive excision and reconstructed with the free flap with good results including one case diagnosed with chronic fatigue syndrome and severe skin adjuvant infiltration, and 2 patients including skin ulcers.
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