Abstract
Bacterial infection and toxic metal ions releasing are the challenges in the clinical application of Ti6Al4V alloy implant materials. Copper is a kind of long-acting, broad-spectrum and safe antibacterial element, and Ta2O5 has good corrosion resistance, wear-resistance and biocompatibility, they are considered and chosen as a potential coating candidate for implant surface modification. In this paper, magnetron sputtering technology was used to prepare copper doped Ta2O5 multilayer composite coating Cu-Ta2O5/Ta2O5/Ta2O5-TiO2/TiO2/Ti (Cu-MTa2O5 for short) on Ti6Al4V alloy surface, for studying the effect of copper incorporation on the microstructure, wettability, anticorrosion and antibacterial activities of the composite coating. The results showed that Cu-MTa2O5 coating obviously improves the hydrophobicity, corrosion resistance and antibacterial property of Ti6Al4V alloy. In the coating, both copper and Ta2O5 exhibit an amorphous structure and copper mainly presents as an oxidation state (Cu2O and CuO). With the increase of the doping amount of copper, the grain size, roughness, and hydrophobicity of the modified surface of Ti6Al4V alloy are increased. Electrochemical experiment results demonstrated that the corrosion resistance of Cu-MTa2O5 coated Ti6Al4V alloy slightly decreased with the increase of copper concentration, but this coating still acts strong anticorrosion protection for Ti6Al4V alloy. Moreover, the Cu-MTa2O5 coating can kill more than 97% of Staphylococcus aureus in 24 h, and the antibacterial rate increases with the increase of copper content. Therefore, Cu-MTa2O5 composite coating is a good candidate for improving anticorrosion and antibacterial properties of Ti6Al4V alloy implant medical devices.
Highlights
Reducing postoperative pain and the probability of postoperative complications, and speeding up the recovery of patients are both urgent problems to be addressed in the clinical application of implant materials [1]
Since the corrosion and infection of implant materials are highly related to their surface properties, surface modification is considered to be the most effective method to overcome the problems in the clinical application of implant materials [7]
As shown in this Figure, the surface of all samples is composed of peak-type particles, the particle size is increased with the increasing of doped Cu element
Summary
Reducing postoperative pain and the probability of postoperative complications, and speeding up the recovery of patients are both urgent problems to be addressed in the clinical application of implant materials [1]. It was found by clinical studies that Ti6Al4V titanium alloy could be corroded by body fluids, releasing metal ions with the toxic and side effects, such as aluminum and vanadium, which could induce inflammation, allergy, poisoning and other reactions in human body, subsequently lead to the failure of implant surgery in serious cases [6,38]. For the further understanding of the influence of copper content on the microstructure and properties of the coating, the Cu-MTa2 O5 multilayer composite coating with different copper content was prepared on Ti6Al4V by magnetron sputtering in this study. 2O5 multilayer composite coatings the first study the effect of copper doping on of theTa microstructure and properties of Ta2 Oon multilayer titanium alloys.
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