Abstract
The article presents the histological studies of replacement chickens’ spleen. The predominance of medium lymphocytes over small ones in the periarterial area was noted after vaccination with “Raspol” being an immunostimulant against chicken infectious bronchitis. In the periarterial area, the predominance of medium lymphocytes over small ones was noted. The lumen profiles of the central, trabecular arteries were well defined, and there were no signs of connective tissue disorganization in their walls. The marginal part of the lymph nodules also remained well defined especially from the inner border and consisted of a large number of small lymphocytes and fewer medium ones. However, its width decreased markedly compared to the previous period of the organ examination. The indicated changes denote the signs of lymphoid cell hyperplasia in the lymph nodes, with a weak severity or absence of the consequences of the vaccine reactogenic effect on the connective tissue of the organ. In the birds receiving Fosprenil during immunization, the stimulation of lymphoproliferative activity continued during the first two weeks after vaccination and by the end of the one-month period it was not detected. However, signs of moderate postvaccination disorganization of the connective tissue components were observed at all follow-up periods. 28 days after vaccination, lymphoproliferative processes weakened markedly and signs accompanied by moderate disorganization of the components in connective tissue persisted in the spleen of the control group of birds.
Highlights
Poultry farming is one of the most important sources of food resources replenishment
The purpose of the work is to study the effect of plant heteropolysaccharidan on the microstructure of chickens’ spleen when combined with the vaccine against chicken infectious bronchitis
Control group was represented by 25 birds vaccinated without an immunostimulant against chicken infectious bronchitis
Summary
Poultry farming is one of the most important sources of food resources replenishment. The products of this industry are distinguished by high consumer properties, and by greater availability and affordability in comparison with other animal-derived products. The basis of Russian poultry farming is large industrial-type poultry enterprises, where research work outcomes are being effectively implemented [1]. Russian poultry farming is undoubtedly a leader in the market of livestock products. A successful industrial poultry farming can be achieved through the introduction of new technologies, augmenting a livestock with species and crosses of birds with high genetic potential and growth rate, and through the use of new pharmacological developments and methods for improving the health of farm birds [3]. A judgment on the safety of immunomodulators is currently based on toxicity studies conducted on laboratory and other types of animals [4,5,6,7,8,9]
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