Abstract
The objective of this study was to quantify microstructural remodeling in peri-infarcted and infarcted porcine myocardium using diffusion tensor MRI (DT-MRI) for the first time. High resolution ex vivo late gadolinium enhanced (LGE) MRI was used to segment the DT-MRI data into normal, peri-infarct and infarcted myocardium. LGE-MRI based segmentation produces regions with significantly different microstructural remodeling.
Highlights
T1-weighted late gadolinium enhanced (LGE) magnetic resonance imaging (MRI) is recognized as the “gold standard” for MRI based myocardial infarct mapping [1]. It is unclear how variations in LGE signal intensity relate to microstructural remodeling
DT invariants provide a basis for evaluating changes in the trace (TR, magnitude-of-isotropic-diffusion), fractional anisotropy (FA, magnitude-of-anisotropy), and the tensor mode (MD, type-of-anisotropy) as a consequence of remodeling [2]
Myocardial voxels were segmented as normal, peri-infarct or infarct based on signal intensity (SI) thresholds of the LGE images for each heart
Summary
T1-weighted late gadolinium enhanced (LGE) magnetic resonance imaging (MRI) is recognized as the “gold standard” for MRI based myocardial infarct mapping [1]. It is unclear how variations in LGE signal intensity relate to microstructural remodeling. Diffusion tensor magnetic resonance imaging (DT-MRI) enables 3D evaluation of soft tissue microstructure. DT invariants provide a basis for evaluating changes in the trace (TR, magnitude-of-isotropic-diffusion), fractional anisotropy (FA, magnitude-of-anisotropy), and the tensor mode (MD, type-of-anisotropy) as a consequence of remodeling [2]. The objective of this study was to use high resolution ex vivo LGE MRI of postinfarct porcine hearts to segment remote, peri-infarcted
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