Abstract
be increased by the time of the conference. Associations with cognitive performance and grey matter atrophy, and further DTI metrics will be presented. Results: At baseline, PCA patients showed lower in FA compared to tAD patients in the splenium of the corpus callosum (p1⁄40.03), and the posterior thalamic radiation in the left (p1⁄40.03) and right hemispheres (p1⁄40.02). PCA patients showed greater reduction in FA (annualised % change) in the splenium (p1⁄40.03) and right posterior thalamic radiation (p1⁄40.04) than tAD patients. Similar results are seen in increased MD (see Table 1) with additional differences in posterior corona radiata and cingulum (right), and SLF (right) longitudinally. Conclusions: The results reveal differences in DTI metrics which likely reflect greater alterations to WM microstructure in PCA than tAD, particularly in the right hemisphere. This study has implications for our understanding of the progression of AD, with the potential for new methods of tracking disease progression. This study also contributes to our understanding of the relative sparing and vulnerability in different EOAD phenotypes.
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