Abstract
This article presents longitudinal 1H-MR Spectroscopy (1H-MRS) data from ventral hippocampus and in vivo diffusion MRI (dMRI) data of the brain from control and anhedonic rats. The 1H-MRS and dMRI data were acquired using a 9.4 T preclinical imaging system. Before MRI experiments, animals were exposed to unpredictable chronic mild stress exposure for eight weeks and on the basis of a sucrose consumption test were identified as anhedonic and resilient. An age-matched group of animals, unexposed to the unpredictable chronic mild stress paradigm was considered as control. Data was acquired at the age of 18, 20 and 25 weeks in the anhedonic group and at the age of 18 and 22 weeks in the control group. This multimodal MRI data provides metabolic information of ventral hippocampus and dMRI based microstructural parameters of the brain.
Highlights
Unpredictable Chronic exposure to mild stressors (CMS) exposure on rats is considered as a realistic model with demonstrated face, predictive, etiological and construct validity [2]
The article presented here utilized an in vivo diffusion MRI based approach to assess microstructural recovery of the stress sensitive brain regions and metabolic recovery of a ventral hippocampal region in CMS-induced anhedonic rats in comparison to age matched controls
Long Evans rats were exposed to a CMS paradigm for eight weeks and were identified as anhedonic (CMS responders) and resilient (CMS non-responders) based on a weekly sucrose consumption test [2]
Summary
Chronic exposure to mild stressors (CMS) may lead to depression and other psychiatric disorders [1]. The animal model of depression can help to elucidate underlying metabolic and microstructural alterations in stress sensitive regions of the brain in comparison to controls. Stress sensitive brain regions, such as the hippocampus [3,4], prefrontal cortex [5,6], amygdala [7,8] and caudate putamen [9] have shown microstructural alterations in cadaver brains of patients with depressive disorder and in the brains of the animal model of depression. The article presented here utilized an in vivo diffusion MRI (dMRI) based approach to assess microstructural recovery of the stress sensitive brain regions and metabolic recovery of a ventral hippocampal region in CMS-induced anhedonic rats in comparison to age matched controls. Anhedonic rats were longitudinally scanned under in vivo MRI at the age. The data provided here could be useful for researchers planning a neuroimaging study of an animal model of depression or for doing follow-up analysis as it may provide insight into the neuroimaging of depression, which is useful for diagnosis or prognosis of patients with depressive disorder
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
