Abstract
Microsponge is developing field of technology which can achieve goal of site specific as well as controlled drug delivery. Physicochemical properties of microsponge like Particle size, particle size distribution, porosity, surface morphology plays a major role in selection of type of dosage form and route of administration for delivery of drug. Microsponge is also emerged as novel tool for delivering of drug by topical route. Topical route is having added advantage of formulation flexibility, greater patient compliance, improved safety and efficacy of formulation and aesthetic properties. Rheumatoid Arthritis is immunomodulatory disease which requires long term treatment for management of disease. Available oral formulation may cause liver toxicity upon long term use. Topical route can be suitable alternate route for delivery of drug with enhanced stability of drug, reduced side effects, and reduced frequency of administration. Due to porous and spongy structure of Microsponge, it has the capacity to entrap large amount of dose and can modify drug release too.
Highlights
Arthritis is an immunomodulatory disease that mainly causes inflammation of the joints which can affect a single or multiple joints
Polymerization of monomer present in suspension is promoted by catalyst, temperature or radiation (Fig. 2)
Microsponges are separated from reaction media and subjected for drying [20,33,34]
Summary
Arthritis is an immunomodulatory disease that mainly causes inflammation of the joints which can affect a single or multiple joints It affects mainly geriatric patient but sometimes observed in young age children. Due to large porous surface, it is capable to release drug for a longer period of time, in a controlled manner [17,18,19] It is stable for a wide range of pH and temperature [20]. Microsponge based topical drug delivery offers additional advantage of localized and site specific drug delivery. It bypasses first pass hepatic metabolism as well as side effects upon oral administration of drug [29,30,31,32]. The average pore size of micro sponges in small in a way to prevent the penetration of bacteria, they do not need sterilization or addition of preservatives
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