Microspheres by Spray Drying: An Approach to Enhance Solubility of Bicalutamide

Abstract

A major challenge in the drug development and delivery process is improving aqueous solubility and rate of dissolution of drugs, which ultimately improves absorption of the drug. Bicalutamide is most useful drug in prostate cancer treatment it is a non-steroidal antiandrogen. It comes under class of poorly water-soluble drug. Poor water-solubility of drugs leads to slow drug absorption, and low bioavailability, for which its solubility is to be enhanced to improve the oral bioavailability of the. One of the possible way to overcome this outcome is to use formulate solid dispersion by using spray drying technique. Spray-drying is a unit operation by which a liquid product is atomized in a hot gas current to instantaneously obtain a powder. The purpose of this research was to improve the solubility profile of Bicalutamide by spray drying technique using Methanol and Polyvinyl pyrolidone-K30. Prepared solid dispersions were evaluated for drug release profile. The compatibility was studied by Fourier Transforms Infrared spectroscopy (FTIR). Prepared Microspheres were subjected to various physicochemical evaluations and in-vitro dissolution profile. The effects of different concentrations of polymer on Solubility enhancement were studied.