Abstract
This chapter describes a computational analysis of the interstitial fluid flow in a single osteocyte canaliculus, which is closely associated with cellular mechanotransduction. A three-dimensional simulation model of an osteocyte process within a canaliculus was reconstructed based on serial tomographic images obtained by ultra-high voltage electron microscopy. The fluid flow simulation predicts the generation of highly inhomogeneous flow patterns in the pericellular space, owing to the microscopic surface roughness of the canalicular wall and the osteocyte process. These flow patterns may contribute to the amplification of mechanical stimuli to osteocytes through deformation of cytoskeletal elements in the cell processes.
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