Microscopic colitis of incomplete collagen type in combination with lactase deficiency

Abstract

The number of patients complaining of indigestion is increasing every year. Made a significant contribution to this the COVID-19 pandemic, which has been going on for almost 3 years, led to this, the drugs used to treat the infection and its complications have a negative effect on the gastrointestinal tract, not to mention the most damaging effect of the virus. Against the backdrop of an increasing number of patients with indigestion as a result of COVID-19, it is important not to forget about other diseases that do not lie on the surface and do not always have typical manifestations. A relatively young disease, but increasingly common among patients with diarrhea, is microscopic colitis (MC). This article presents a clinical case of microscopic colitis of incomplete collagen type in combination with lactase deficiency. MC is a chronic inflammatory bowel disease of unknown etiology, characterized by chronic watery diarrhea, the absence of macroscopic signs of colon damage in the presence of specific pathomorphological changes. Based on the histological result, two main forms are distinguished: collagenous and lymphocytic colitis. According to the latest data presented in the European guidelines, the overall prevalence of MC is 119.4 cases per 100 thousand people, and the incidence is 11.4 cases per 100 thousand population per year. The progressive increase in the incidence, and even the prevalence of MC over patients with inflammatory bowel disease (IBD) in some countries in the group over 60 years of age, has led to an increase in clinical interest in this problem, improvement of diagnostic methods and revision of clinical guidelines in February 2021. Given the increase in the incidence of MC, the difficult diagnostic search for this diagnosis, age variation, and the description of clinical cases that differ from the average portraits of a “typical patient” with microscopic colitis are of clinical interest.