Abstract
A sensitive micro-scale method based on isocratic elution reversed-phase ion-pair chromatography for the determination of bamifylline and its major metabolite (AC 119) in human plasma is described. The method is based on a liquid—liquid extraction clean-up followed by analysis on an LC-Packings Fusica (Delta Pak, RP-18, 5 μm, 300 Å) column (15 cm × 330 μm, I.D.) with 0.03 M heptanesulphonate (pH 3.5)-acetonitrile (7:3, v/v) as the mobile phase. Data with respect to recovery, reproducibility and limits of detection are reported and discussed.
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