Abstract
BackgroundMicrosatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide units in microsatellites. High-frequency MSI (MSI-H) colorectal cancers (CRCs) are known to have different clinicopathological features compared with microsatellite stable (MSS) CRCs. In addition, previous studies have shown that type2 diabetes mellitus (T2DM) is a risk factor for malignant tumors including CRCs. The aim of this study was to investigate the relationship between T2DM and MSI-H colorectal cancer.MethodsThe study design is a single center, cross-sectional study. Data from a series of 936 patients with CRCs were collected and MSI status was assessed.ResultsIn total, 29 (3.1%) and 907 (96.9%) tumors were classified as having MSI-H and low-frequency microsatellite instability or being MSS (MSS), respectively. Of the 936 patients, 275 (29.6%) were associated with T2DM. One (3.4%) of the 29 MSI-H patients and 274 (30.2%) of the 907 MSS patients had T2DM. Thus, the incidence of T2DM was significantly less frequent in MSI-H compared with MSS patients (Fisher’s exact test: p = 0.0007).ConclusionsWe conclude that MSS tumors are significantly more common than MSI-H tumors among individuals with T2DM.
Highlights
Colorectal cancer (CRC) is one of the most common solid tumors, and details associated with its carcinogenesis have been intensively studied
29 (3.1%) and 907 (96.9%) tumors were classified as having MSI-H and low-frequency microsatellite instability or being microsatellite stable (MSS) (MSS), respectively
The incidence of type2 diabetes mellitus (T2DM) was significantly less frequent in MSI-H compared with MSS patients (Fisher’s exact test: p = 0.0007)
Summary
Colorectal cancer (CRC) is one of the most common solid tumors, and details associated with its carcinogenesis have been intensively studied. Some colorectal cancers are microsatellite stable (MSS). No MSI tumor shows LOH at these tumor suppressor genes [7], and target genes for frameshift mutations in CRCs are different from those in MSS tumors. Testing colorectal cancers for MSI is an effective method of screening for Lynch syndrome because approximately 90% of Lynch syndrome tumors have high microsatellite instability (MSI-H) [11]. High-frequency MSI (MSI-H) colorectal cancers (CRCs) are known to have different clinicopathological features compared with microsatellite stable (MSS) CRCs. In addition, previous studies have shown that type diabetes mellitus (T2DM) is a risk factor for malignant tumors including CRCs. The aim of this study was to investigate the relationship between T2DM and MSI-H colorectal cancer
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