Abstract
Microsatellite instability (MSI) is found in nearly all Lynch syndrome colorectal cancers and in about half of serrated pathway cancers. Because serrated pathway cancer is more common, it produces about 80% of all microsatellite-unstable tumors. Current recommendations are to screen all colorectal cancers for MSI or failed expression of mismatch repair proteins. Positive tests for MSI or failure to express mismatch repair protein MLH1 should be followed by BRAF mutation tests or hypermethylation assays to …
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